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Tcl1 rabbit pAb
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ES8608
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: Tcl1 rabbit pAb
反应性: Human;Rat;Mouse;
别名: T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1)
宿主: Rabbit
稀释比: WB 1:500-2000, ELISA 1:10000-20000
免疫原: Synthetic peptide from human protein at AA range: 30-110
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 13kD
基因ID: 8115
蛋白序列: P56279
细胞定位: Cytoplasm . Nucleus . Microsome . Endoplasmic reticulum . Microsomal fraction.
研究背景: Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010],
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