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HLA Class I rabbit pAb
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ES8555
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: HLA Class I rabbit pAb
反应性: Human
别名: HLA-A HLAA
宿主: Rabbit
稀释比: WB 1:500-2000, ELISA 1:10000-20000
免疫原: The antiserum was produced against synthesized peptide derived from human HLA Class I. AA range:204-253
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 40kD
蛋白序列: P01891/P01892/P04439/P05534/P10314/P10316/P13746/P16189/P18462/P30443/P30450/P30453/P30455/P30456/P30457/P30512/Q09160
细胞定位: Golgi membrane,endoplasmic reticulum,Golgi apparatus,Golgi medial cisterna,plasma membrane,integral component of plasma membrane,cell surface,ER to Golgi transport vesicle membrane,membrane,integral component of membrane,
研究背景: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney trans
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