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COL25A1 rabbit pAb
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ES8542
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: COL25A1 rabbit pAb
反应性: Human;Mouse
别名: COL25A1
宿主: Rabbit
稀释比: WB 1:500-2000, ELISA 1:10000-20000
免疫原: Synthetic peptide from human protein at AA range: 101-150
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 64kD
基因ID: 84570
蛋白序列: Q9BXS0
细胞定位: Membrane ; Single-pass type II membrane protein . After proteolytic cleavage, CLAC is secreted.
研究背景: This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
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