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Collagen IV rabbit pAb
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ES8486
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: Collagen IV rabbit pAb
反应性: Human;Mouse;Rat
别名: collagen, type IV, alpha 1
宿主: Rabbit
稀释比: WB 1:500-2000, ELISA 1:10000-20000
免疫原: Synthesized peptide derived from Collagen IV . at AA range: 1428-1443
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 130kD
基因ID: 1282
蛋白序列: P02462
细胞定位: Secreted, extracellular space, extracellular matrix, basement membrane .
研究背景: This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
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