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Neurexin I rabbit pAb
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ES8030
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: Neurexin I rabbit pAb
反应性: Human;Mouse;Rat
别名: NRXN1; KIAA0578; Neurexin-1-alpha; Neurexin I-alpha
宿主: Rabbit
稀释比: WB 1:500-2000;IHC-p 1:50-300
免疫原: The antiserum was produced against synthesized peptide derived from human NRXN1. AA range:502-551
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 150kD
基因ID: 9378
蛋白序列: Q9ULB1
细胞定位: Cell junction, synapse, presynaptic cell membrane ; Single-pass type I membrane protein .
研究背景: NRXN1 (neurexin 1) encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for NRXN1 in the 3' region. Mutations in NRXN1 are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.
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