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Cyclin D3 rabbit pAb
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ES7915
规格: 价格:
50µL ¥1280.00
100µL ¥1980.00

Overview

产品名称: Cyclin D3 rabbit pAb
反应性: Human;Mouse;Rat;Monkey
别名: CCND3; G1/S-specific cyclin-D3
宿主: Rabbit
稀释比: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
免疫原: The antiserum was produced against synthesized peptide derived from human Cyclin D3. AA range:243-292
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 32kD
基因ID: 896
蛋白序列: P30281
细胞定位: Nucleus . Cytoplasm .
研究背景: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008],
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