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TGIF rabbit pAb
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ES7383
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: TGIF rabbit pAb
反应性: Human;Mouse;Rat
别名: TGIF1; TGIF; Homeobox protein TGIF1; 5'-TG-3'-interacting factor 1
宿主: Rabbit
稀释比: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
免疫原: Synthesized peptide derived from the C-terminal region of human TGIF.
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 43kD
基因ID: 7050
蛋白序列: Q15583
细胞定位: Nucleus.
研究背景: The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provide
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