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PAF-R rabbit pAb
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ES6880
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: PAF-R rabbit pAb
反应性: Human;Mouse;Rat
别名: PTAFR; PAFR; Platelet-activating factor receptor; PAF-R; PAFr
宿主: Rabbit
稀释比: Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
免疫原: The antiserum was produced against synthesized peptide derived from human PTAFR. AA range:194-243
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
分子量: 39kD
基因ID: 5724
蛋白序列: P25105
细胞定位: Cell membrane ; Multi-pass membrane protein .
研究背景: This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],
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