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ATP7B rabbit pAb
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ES6635
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: ATP7B rabbit pAb
反应性: Human;Mouse;Rat
别名: ATP7B; PWD; WC1; WND; Copper-transporting ATPase 2; Copper pump 2; Wilson disease-associated protein
宿主: Rabbit
稀释比: Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
免疫原: The antiserum was produced against synthesized peptide derived from human ATP7B. AA range:161-210
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
分子量: 157kD
基因ID: 540
蛋白序列: P35670
细胞定位: Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein . Late endosome . Predominantly found in the trans-Golgi network (TGN). Localized in the trans-Golgi network under low copper conditions, redistributes to cytoplasmic vesicles when cells are exposed to elevated copper levels, and then recycles back to the trans-Golgi network when copper is removed (PubMed:10942420). .; [Isoform 1]: Golgi apparatus membrane ; Multi-pass membrane protein .; [Isoform 2]: Cytoplasm .; [WND/140 kDa]: Mitochondrion .
研究背景: This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). [provided by RefSeq, Jul 2008],
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