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tPA rabbit pAb
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ES6601
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: tPA rabbit pAb
反应性: Human;Mouse;Rat
别名: PLAT; Tissue-type plasminogen activator; t-PA; t-plasminogen activator; tPA; Alteplase; Reteplase
宿主: Rabbit
稀释比: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
免疫原: The antiserum was produced against synthesized peptide derived from human tPA. AA range:38-87
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 63kD
基因ID: 5327
蛋白序列: P00750
细胞定位: Secreted, extracellular space.
研究背景: This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016],
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