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Claudin-11 rabbit pAb
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ES6450
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: Claudin-11 rabbit pAb
反应性: Human;Mouse;Rat
别名: CLDN11; OSP; OTM; Claudin-11; Oligodendrocyte-specific protein
宿主: Rabbit
稀释比: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
免疫原: The antiserum was produced against synthesized peptide derived from human Claudin 11. AA range:158-207
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 20kD
基因ID: 5010
蛋白序列: O75508
细胞定位: Cell junction, tight junction. Cell membrane ; Multi-pass membrane protein .
研究背景: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different iso
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