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Integrin β4 (phospho Tyr1510) rabbit pAb
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ES5957
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: Integrin β4 (phospho Tyr1510) rabbit pAb
反应性: Human;Mouse;Rat
别名: ITGB4; Integrin beta-4; GP150; CD antigen CD104
宿主: Rabbit
稀释比: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
免疫原: The antiserum was produced against synthesized peptide derived from human ITGB4 around the phosphorylation site of Tyr1510. AA range:1481-1530
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 202kD
基因ID: 3691
蛋白序列: P16144
细胞定位: Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Colocalizes with DST at the leading edge of migrating keratinocytes.
研究背景: Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
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