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mGluR2 rabbit pAb
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ES5674
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: mGluR2 rabbit pAb
反应性: Human;Mouse;Rat
别名: GRM2; GPRC1B; MGLUR2; Metabotropic glutamate receptor 2; mGluR2
宿主: Rabbit
稀释比: Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
免疫原: The antiserum was produced against synthesized peptide derived from human GRM2. AA range:241-290
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
分子量: 96kD
基因ID: 2912
蛋白序列: Q14416
细胞定位: Cell membrane; Multi-pass membrane protein. Cell junction, synapse . Cell projection, dendrite .
研究背景: glutamate metabotropic receptor 2(GRM2) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene
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