Shank 2 rabbit pAb-ELK科鹿生物-ELISA试剂盒、抗体、蛋白、分子

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Shank 2 rabbit pAb

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ES5277

规格：	价格：
50µL	￥1280.00
100µL	￥1980.00

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Overview

产品名称:	Shank 2 rabbit pAb
反应性:	Human;Rat;Mouse;
别名:	SHANK2; CORTBP1; KIAA1022; SH3 and multiple ankyrin repeat domains protein 2; Shank2; Cortactin-binding protein 1; CortBP1; Proline-rich synapse-associated protein 1
宿主:	Rabbit
稀释比:	WB 1:500-2000;IHC-p 1:50-300
免疫原:	The antiserum was produced against synthesized peptide derived from human SHANK2. AA range:331-380
储存条件:	-20°C/1 year
克隆性:	Polyclonal
抗体亚型:	IgG
浓度:	1 mg/ml
实测条带:	135kD
基因ID:	22941
蛋白序列:	Q9UPX8
细胞定位:	Apical cell membrane . Cytoplasm . Cell junction, synapse . Cell junction, synapse, postsynaptic density . Cell projection, growth cone . Cell projection, dendritic spine . Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells (By similarity). .
研究背景:	This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014],

Western Blot analysis of RAW264.7 cells using Shank 2 Polyclonal Antibody
Western blot analysis of lysates from RAW264.7, Jurkat, HepG2, and COLO cells, using SHANK2 Antibody. The lane on the right is blocked with the synthesized peptide.
Western blot analysis of the lysates from HT-29 cells using SHANK2 antibody.
Immunohistochemical analysis of paraffin-embedded human cervical carcinoma. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).

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