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Eps15 (phospho Tyr849) rabbit pAb
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ES5140
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: Eps15 (phospho Tyr849) rabbit pAb
反应性: Human;Mouse;Rat
别名: EPS15; AF1P; Epidermal growth factor receptor substrate 15; Protein Eps15; Protein AF-1p
宿主: Rabbit
稀释比: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
免疫原: Synthesized phospho-peptide around the phosphorylation site of human Eps15 (phospho Tyr849)
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 100kD
基因ID: 2060
蛋白序列: P42566
细胞定位: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes. .; [Isoform 2]: Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Colocalizes with HGS on bilayered clathrin coats on endosomes.
研究背景: This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009],
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