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PSGL-1 rabbit pAb
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ES4302
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: PSGL-1 rabbit pAb
反应性: Human;Rat;Mouse;
别名: SELPLG; P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD162
宿主: Rabbit
稀释比: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
免疫原: The antiserum was produced against synthesized peptide derived from the N-terminal region of human SELPLG. AA range:1-50
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 45 110kd(glycosylated)
基因ID: 6404
蛋白序列: Q14242
细胞定位: Membrane; Single-pass type I membrane protein.
研究背景: This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011],
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