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MCM6 rabbit pAb
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ES4184
规格: 价格:
50µL ¥1280.00
100µL ¥1980.00

Overview

产品名称: MCM6 rabbit pAb
反应性: Human;Mouse;Rat
别名: MCM6; DNA replication licensing factor MCM6; p105MCM
宿主: Rabbit
稀释比: WB 1:500-2000;IHC-p 1:50-300
免疫原: The antiserum was produced against synthesized peptide derived from the Internal region of human MCM6. AA range:331-380
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 90kD
基因ID: 4175
蛋白序列: Q14566
细胞定位: Nucleus . Chromosome . Binds to chromatin during G1 and detach from it during S phase. .
研究背景: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, i
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