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Apaf-1 rabbit pAb
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ES4108
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: Apaf-1 rabbit pAb
反应性: Human;Mouse;Rat
别名: APAF1; KIAA0413; Apoptotic protease-activating factor 1; APAF-1
宿主: Rabbit
稀释比: Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
免疫原: The antiserum was produced against synthesized peptide derived from the Internal region of human APAF1. AA range:501-550
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 135kD
基因ID: 317
蛋白序列: O14727
细胞定位: Cytoplasm .
研究背景: This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
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