SYCP3; SCP3; Synaptonemal complex protein 3; SCP-3
Source:
Rabbit
Dilutions:
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Immunogen:
Synthesized peptide derived from the Internal region of human SCP-3.
Storage:
-20°C/1 year
Clonality:
Polyclonal
Isotype:
IgG
Concentration:
1 mg/ml
Observed Band:
27kD
GeneID:
50511
Human Swiss-Prot No:
Q8IZU3
Cellular localization:
Nucleus . Chromosome . Chromosome, centromere . It is present in early unpaired cores, in the lateral domains of the synaptonemal complex and in the chromosome cores when they separate at diplotene. It is found axial to the metaphase I chromosomes and in association with pairs of sister centromeres. The centromere-associated protein becomes dissociated from the centromeres at anaphase II and is not found in mitotic metaphase centromeres. .
Background:
This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010],