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NPRL2 rabbit pAb
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ES3816
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: NPRL2 rabbit pAb
反应性: Human;Mouse;Rat
别名: NPRL2; TUSC4; Nitrogen permease regulator 2-like protein; NPR2-like protein; Gene 21 protein; G21 protein; Tumor suppressor candidate 4
宿主: Rabbit
稀释比: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
免疫原: Synthesized peptide derived from the C-terminal region of human NPRL2.
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 43kD
基因ID: 10641
蛋白序列: Q8WTW4
细胞定位: Lysosome membrane . Localization to lysosomes is amino acid-independent. .
研究背景: function:Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.,similarity:Belongs to the NPR2 family.,subunit:Interacts with PDPK1.,tissue specificity:Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.,
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