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Vav1 rabbit pAb
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ES3690
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: Vav1 rabbit pAb
反应性: Human;Mouse;Rat
别名: VAV1; VAV; Proto-oncogene vav
宿主: Rabbit
稀释比: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
免疫原: The antiserum was produced against synthesized peptide derived from human VAV1. AA range:141-190
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 98kD
基因ID: 7409
蛋白序列: P15498
细胞定位: intracellular,cytosol,plasma membrane,cell-cell junction,
研究背景: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012],
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