PUMA rabbit pAb-科鹿（武汉）生物科技有限责任公司

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PUMA rabbit pAb

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ES3285

规格：	价格：
50µL	￥1280.00
100µL	￥1980.00

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Overview

Product name:	PUMA rabbit pAb
Reactivity:	Human;Mouse;Rat
Alternative Names:	BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis
Source:	Rabbit
Dilutions:	WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.
Immunogen:	The antiserum was produced against synthesized peptide derived from human PUMA. AA range:120-169
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	23kD
GeneID:	27113
Human Swiss-Prot No:	Q9BXH1
Cellular localization:	Mitochondrion . Localized to the mitochondria in order to induce cytochrome c release.
Background:	This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],

Immunofluorescence analysis of A549. 1,primary Antibody was diluted at 1:200(4°C overnight). 2, Goat Anti Rabbit IgG (H&L) - Alexa Fluor 488 Secondary antibody was diluted at 1:1000(room temperature, 50min).3, Picture B: DAPI(blue) 10min.
Western Blot analysis of various cells using PUMA Polyclonal Antibody
Western blot analysis of lysate from 293 cells treated with EGF, using PUMA antibody.

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