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ORC1 rabbit pAb
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ES3085
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: ORC1 rabbit pAb
反应性: Human;Rat;Mouse;
别名: ORC1; ORC1L; PARC1; Origin recognition complex subunit 1; Replication control protein 1
宿主: Rabbit
稀释比: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
免疫原: The antiserum was produced against synthesized peptide derived from human ORC1L. AA range:331-380
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 100,120kD
基因ID: 4998
蛋白序列: Q13415
细胞定位: Nucleus.
研究背景: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcr
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