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MBD3 rabbit pAb
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ES2756
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: MBD3 rabbit pAb
反应性: Human;Mouse
别名: MBD3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3
宿主: Rabbit
稀释比: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
免疫原: The antiserum was produced against synthesized peptide derived from human MBD3. AA range:221-270
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 33kD
基因ID: 53615
蛋白序列: O95983
细胞定位: Nucleus. Chromosome. Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes.
研究背景: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013],
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