Frizzled-7 rabbit pAb-科鹿（武汉）生物科技有限责任公司

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Frizzled-7 rabbit pAb

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ES2373

规格：	价格：
50µL	￥1280.00
100µL	￥1980.00

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Overview

Product name:	Frizzled-7 rabbit pAb
Reactivity:	Human;Mouse
Alternative Names:	FZD7; Frizzled-7; Fz-7; hFz7; FzE3
Source:	Rabbit
Dilutions:	WB 1:500-2000;Flow Cyt 1:50-200;IF/ICC 1:100-500;ELISA 1:5000-20000
Immunogen:	The antiserum was produced against synthesized peptide derived from human FZD7. AA range:45-94
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	64kD
GeneID:	8324
Human Swiss-Prot No:	O75084
Cellular localization:	Cell membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions. .
Background:	frizzled class receptor 7(FZD7) Homo sapiens Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008],

Immunofluorescence analysis of A549. 1,primary Antibody(red) was diluted at 1:200(4°C overnight). 2, Goat Anti Rabbit IgG (H&L) - Alexa Fluor 594 Secondary antibody was diluted at 1:1000(room temperature, 50min).3, Picture B: DAPI(blue) 10min.
Western Blot analysis of various cells using Frizzled-7 Polyclonal Antibody diluted at 1:2000
Western Blot analysis of HELA cells using Frizzled-7 Polyclonal Antibody diluted at 1:2000
Immunofluorescence analysis of MCF7 cells, using FZD7 Antibody. The picture on the right is blocked with the synthesized peptide.

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