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Fibulin-5 rabbit pAb
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ES2344
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: Fibulin-5 rabbit pAb
反应性: Human;Mouse;Rat
别名: FBLN5; DANCE; Fibulin-5; FIBL-5; Developmental arteries and neural crest EGF-like protein; Dance; Urine p50 protein; UP50
宿主: Rabbit
稀释比: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
免疫原: The antiserum was produced against synthesized peptide derived from human FBLN5. AA range:171-220
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 50kD
基因ID: 10516
蛋白序列: Q9UBX5
细胞定位: Secreted . Secreted, extracellular space, extracellular matrix . co-localizes with ELN in elastic fibers. .
研究背景: The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008],
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