ErbB-3 rabbit pAb-ELK科鹿生物-ELISA试剂盒、抗体、蛋白、分子

产品中心

ErbB-3 rabbit pAb

一键复制产品信息

ES2290

规格：	价格：
50µL	￥1280.00
100µL	￥1980.00

下载说明 ①

Overview

产品名称:	ErbB-3 rabbit pAb
反应性:	Human;Mouse;Rat
别名:	ERBB3; HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3
宿主:	Rabbit
稀释比:	Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
免疫原:	The antiserum was produced against synthesized peptide derived from human HER3. AA range:1191-1240
储存条件:	-20°C/1 year
克隆性:	Polyclonal
抗体亚型:	IgG
浓度:	1 mg/ml
实测条带:	148kD
基因ID:	2065
蛋白序列:	P21860
细胞定位:	[Isoform 1]: Cell membrane ; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
研究背景:	This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the m

Western Blot analysis of various cells using ErbB-3 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
Immunofluorescence analysis of HUVEC cells, using HER3 Antibody. The picture on the right is blocked with the synthesized peptide.
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using HER3 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from 293 cells, using HER3 Antibody. The lane on the right is blocked with the synthesized peptide.

关闭

在线咨询

Online consultation

在线咨询
技术支持

关注微信公众号

微信扫一扫立即咨询

微信电脑端咨询

微信扫一扫立即咨询

微信电脑端咨询

关闭