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DMPK rabbit pAb
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ES2180
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: DMPK rabbit pAb
反应性: Human;Rat;Mouse;
别名: DMPK; DM1PK; MDPK; Myotonin-protein kinase; MT-PK; DM-kinase; DMK; DM1 protein kinase; DMPK; Myotonic dystrophy protein kinase
宿主: Rabbit
稀释比: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
免疫原: The antiserum was produced against synthesized peptide derived from human DMPK. AA range:11-60
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 70kD
基因ID: 1760
蛋白序列: Q09013
细胞定位: Endoplasmic reticulum membrane ; Single-pass type IV membrane protein ; Cytoplasmic side . Nucleus outer membrane ; Single-pass type IV membrane protein ; Cytoplasmic side . Mitochondrion outer membrane ; Single-pass type IV membrane protein . Sarcoplasmic reticulum membrane . Cell membrane . Cytoplasm, cytosol . Localizes to sarcoplasmic reticulum membranes of cardiomyocytes. .; [Isoform 1]: Mitochondrion membrane.; [Isoform 3]: Mitochondrion membrane.
研究背景: The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2016],
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