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FH rabbit pAb
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ES20754
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: FH rabbit pAb
反应性: Human;Mouse;Rat
别名: Fumarate hydratase, mitochondrial (Fumarase) (EC 4.2.1.2)
宿主: Rabbit
稀释比: WB: 1:1000
免疫原: Recombinant Protein of Fumarate hydratase, mitochondrial
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
实测条带: 50kD
基因ID: 2271
蛋白序列: P07954
细胞定位: [Isoform Mitochondrial]: Mitochondrion .; [Isoform Cytoplasmic]: Cytoplasm, cytosol . Nucleus . Chromosome . Translocates to the nucleus in response to DNA damage: localizes to DNA double-strand breaks (DSBs) following phosphorylation by PRKDC. .
研究背景: The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq, Jul 2008],
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