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MeCP2 rabbit pAb
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ES20671
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: MeCP2 rabbit pAb
反应性: Human
别名: Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)
宿主: Rabbit
稀释比: WB: 1:2000
免疫原: Synthetic Peptide of MeCP2 AA range: 313-363
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
实测条带: 53kD
基因ID: 4204
蛋白序列: P51608
细胞定位: Nucleus . Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci. .
研究背景: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isofor
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