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Bim (phospho-Ser69) rabbit pAb
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ES18054
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: Bim (phospho-Ser69) rabbit pAb
反应性: Human;Mouse
别名: Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death)
宿主: Rabbit
稀释比: WB 1:1000-2000
免疫原: Synthesized phosho peptide around human Bim (Ser69)
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 22kD
基因ID: 10018
蛋白序列: O43521
细胞定位: Endomembrane system ; Peripheral membrane protein . Associated with intracytoplasmic membranes. .; [Isoform BimEL]: Mitochondrion. Translocates from microtubules to mitochondria on loss of cell adherence.; [Isoform BimL]: Mitochondrion.; [Isoform BimS]: Mitochondrion.; [Isoform Bim-alpha1]: Mitochondrion.
研究背景: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013],
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