Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52)
宿主:
Rabbit
稀释比:
WB 1:500-2000
免疫原:
Synthesized peptide derived from human CALCOCO2
储存条件:
-20°C/1 year
克隆性:
Polyclonal
抗体亚型:
IgG
浓度:
1 mg/ml
实测条带:
53kD
基因ID:
10241
蛋白序列:
Q13137
细胞定位:
Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton . Cytoplasmic vesicle, autophagosome membrane ; Peripheral membrane protein . According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot-associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus. .
研究背景:
This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012],