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Ataxin-1 rabbit pAb
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ES1718
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: Ataxin-1 rabbit pAb
反应性: Human;Mouse
别名: ATXN1; ATX1; SCA1; Ataxin-1; Spinocerebellar ataxia type 1 protein
宿主: Rabbit
稀释比: Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
免疫原: The antiserum was produced against synthesized peptide derived from human Ataxin 1. AA range:742-791
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 87kD
基因ID: 6310
蛋白序列: P54253
细胞定位: Cytoplasm . Nucleus . Colocalizes with USP7 in the nucleus. .
研究背景: ataxin 1(ATXN1) Homo sapiens The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted
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