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DGCR8 rabbit pAb
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ES16953
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: DGCR8 rabbit pAb
反应性: Human; Mouse
别名: Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8)
宿主: Rabbit
稀释比: WB 1:500-2000
免疫原: Synthesized peptide derived from human DGCR8 AA range: 467-517
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 85kD
基因ID: 54487
蛋白序列: Q8WYQ5
细胞定位: Nucleus . Nucleus, nucleolus . Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies (PubMed:17159994).
研究背景: This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010],
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