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DUOX1 rabbit pAb
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ES16881
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: DUOX1 rabbit pAb
反应性: Human;Rat
宿主: Rabbit
稀释比: WB 1：500-2000
免疫原: Synthesized peptide derived from human DUOX1 AA range: 1398-1448
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
分子量: 171kD
基因ID: 53905
蛋白序列: Q9NRD9
细胞定位: Apical cell membrane ; Multi-pass membrane protein . Localizes to the apical membrane of epithelial cells.
研究背景: The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012],
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