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FBX32 rabbit pAb
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ES16504
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: FBX32 rabbit pAb
反应性: Human; Mouse;Rat
别名: F-box only protein 32 (Atrogin-1) (Muscle atrophy F-box protein) (MAFbx)
宿主: Rabbit
稀释比: WB 1:500-2000
免疫原: Synthesized peptide derived from human FBX32 AA range: 217-267
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 38kD
基因ID: 114907
蛋白序列: Q969P5
细胞定位: Cytoplasm . Nucleus . Shuttles between cytoplasm and the nucleus.
研究背景: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011],
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