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AChRα10 rabbit pAb
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ES1581
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: AChRα10 rabbit pAb
反应性: Human;Mouse;Rat
别名: CHRNA10; NACHRA10; Neuronal acetylcholine receptor subunit alpha-10; Nicotinic acetylcholine receptor subunit alpha-10; NACHR alpha-10
宿主: Rabbit
稀释比: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
免疫原: The antiserum was produced against synthesized peptide derived from human CHRNA10. AA range:394-443
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 50kD
基因ID: 57053
蛋白序列: Q9GZZ6
细胞定位: Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein .
研究背景: function:Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.,miscellaneous:The hetero-oligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Forms hetero-oligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 hetero-oligomers.,tissue specificity:Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.,
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