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Rad17 (phospho Ser646) rabbit pAb
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ES1536
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: Rad17 (phospho Ser646) rabbit pAb
反应性: Human;Mouse;Rat
别名: RAD17; R24L; Cell cycle checkpoint protein RAD17; hRad17; RF-C/activator 1 homolog
宿主: Rabbit
稀释比: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
免疫原: Synthesized phospho-peptide around the phosphorylation site of human Rad17 (phospho Ser646)
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
分子量: 77kD
基因ID: 5884
蛋白序列: O75943
细胞定位: Nucleus . Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.
研究背景: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, h
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