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MKKS rabbit pAb
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ES14941
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: MKKS rabbit pAb
反应性: Human; Mouse
别名: McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin (Bardet-Biedl syndrome 6 protein)
宿主: Rabbit
稀释比: WB 1:500-2000
免疫原: Synthesized peptide derived from human MKKS AA range: 166-216
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 65kD
基因ID: 8195
蛋白序列: Q9NPJ1
细胞定位: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol . Nucleus . The majority of the protein resides within the pericentriolar material (PCM), a proteinaceous tube surrounding centrioles. During interphase, the protein is confined to the lateral surfaces of the PCM but during mitosis it relocalizes throughout the PCM and is found at the intercellular bridge. The MKSS protein is highly mobile and rapidly shuttles between the cytosol and centrosome.
研究背景: This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins. Mutations in this gene have been observed in patients with Bardet-Biedl syndrome type 6, also known as McKusick-Kaufman syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013],
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