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MLKL (phospho Ser358) rabbit pAb
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ES14935
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: MLKL (phospho Ser358) rabbit pAb
反应性: Human
别名: Mixed lineage kinase domain-like protein
宿主: Rabbit
稀释比: IHC-p 1:100-500;IF/ICC 1:100-500;WB 1:500-2000
免疫原: Synthesized peptide derived from human MLKL (phospho S358)
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 55kD
基因ID: 197259
蛋白序列: Q8NB16
细胞定位: Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). .
研究背景: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
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