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NOD1 rabbit pAb
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ES14472
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: NOD1 rabbit pAb
反应性: Human; Mouse
别名: Nucleotide-binding oligomerization domain-containing protein 1 (Caspase recruitment domain-containing protein 4)
宿主: Rabbit
稀释比: WB 1:500-2000
免疫原: Synthesized peptide derived from human NOD1 AA range: 290-340
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 105kD
基因ID: 10392
蛋白序列: Q9Y239
细胞定位: Cytoplasm. Cell membrane . Apical cell membrane. Basolateral cell membrane. Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells.
研究背景: This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009],
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