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Stat6 (phospho Thr645) rabbit pAb
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ES1408
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: Stat6 (phospho Thr645) rabbit pAb
反应性: Human;Mouse;Rat
别名: STAT6; Signal transducer and activator of transcription 6; IL-4 Stat
宿主: Rabbit
稀释比: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/10000. Not yet tested in other applications.
免疫原: The antiserum was produced against synthesized peptide derived from human STAT6 around the phosphorylation site of Thr645. AA range:612-661
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
分子量: 94kD
基因ID: 6778
蛋白序列: P42226
细胞定位: Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
研究背景: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
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