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Met (phospho Tyr1349) rabbit pAb
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ES1361
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: Met (phospho Tyr1349) rabbit pAb
反应性: Human;Mouse;Rat
别名: MET; Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met
宿主: Rabbit
稀释比: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
免疫原: The antiserum was produced against synthesized peptide derived from human Met around the phosphorylation site of Tyr1349. AA range:1316-1365
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 155kD
基因ID: 4233
蛋白序列: P08581
细胞定位: Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.
研究背景: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016],
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