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RFX5 rabbit pAb
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ES13409
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: RFX5 rabbit pAb
反应性: Human; Mouse
宿主: Rabbit
稀释比: WB 1:500-2000;IHC-p 1:50-300
免疫原: Synthesized peptide derived from human RFX5 AA range: 491-541
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
分子量: 68kD
基因ID: 5993
蛋白序列: P48382
细胞定位: Nucleus.
研究背景: A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq, Jul 2008],
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