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SPTN2 rabbit pAb
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ES12970
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: SPTN2 rabbit pAb
反应性: Human;Rat
宿主: Rabbit
稀释比: WB 1:500-2000;IHC-p 1:50-300
免疫原: Synthesized peptide derived from human SPTN2 AA range: 644-694
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
分子量: 263kD
基因ID: 6712
蛋白序列: O15020
细胞定位: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
研究背景: Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009],
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