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SSRP1 rabbit pAb
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ES12943
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: SSRP1 rabbit pAb
反应性: Human; Mouse;Rat
宿主: Rabbit
稀释比: WB 1：500-2000
免疫原: Synthesized peptide derived from human SSRP1 AA range: 209-259
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
分子量: 78kD
基因ID: 6749
蛋白序列: Q08945
细胞定位: Nucleus . Nucleus, nucleolus . Chromosome . Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci. .
研究背景: The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008],
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