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UBP20 rabbit pAb
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ES12446
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: UBP20 rabbit pAb
反应性: Human; Mouse
宿主: Rabbit
稀释比: WB 1：500-2000
免疫原: Synthesized peptide derived from human UBP20 AA range: 104-154
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
分子量: 101kD
基因ID: 10868
蛋白序列: Q9Y2K6
细胞定位: Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.
研究背景: This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013],
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