Synthesized peptide derived from human protein . at AA range: 250-330
储存条件:
-20°C/1 year
克隆性:
Polyclonal
抗体亚型:
IgG
浓度:
1 mg/ml
实测条带:
36kD
基因ID:
117194
蛋白序列:
Q96LB1
细胞定位:
Cell membrane; Multi-pass membrane protein .
研究背景:
function:Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.,similarity:Belongs to the G-protein coupled receptor 1 family. Mas subfamily.,tissue specificity:Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.,