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Cleaved-Notch 1 (V1754) rabbit pAb
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ES1050
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: Cleaved-Notch 1 (V1754) rabbit pAb
反应性: Human;Mouse;Rat
别名: NOTCH1; TAN1; Neurogenic locus notch homolog protein 1; Notch 1; hN1; Translocation-associated notch protein TAN-1
宿主: Rabbit
稀释比: WB 1:500-2000, IHC-p 1:50-300, IF 1:50-300
免疫原: The antiserum was produced against synthesized peptide derived from human Notch 1. AA range:1735-1784
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 110kD
基因ID: 4851
蛋白序列: P46531
细胞定位: Cell membrane ; Single-pass type I membrane protein .; [Notch 1 intracellular domain]: Nucleus . Following proteolytical processing NICD is translocated to the nucleus. Nuclear location may require MEGF10. .
研究背景: notch 1(NOTCH1) Homo sapiens This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymph
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