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Cleaved-Caspase-9 p35 (D315) rabbit pAb
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ES1009
规格： 价格：
50µL ￥1280.00
100µL ￥1980.00
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Overview

产品名称: Cleaved-Caspase-9 p35 (D315) rabbit pAb
反应性: Human;Rat;Mouse;
别名: CASP9; MCH6; Caspase-9; CASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; ICE-like apoptotic protease 6; ICE-LAP6
宿主: Rabbit
稀释比: WB 1:500-2000, IHC-p 1:50-300, IF 1:50-300
免疫原: The antiserum was produced against synthesized peptide derived from human Caspase 9. AA range:266-315
储存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 35 46kD
基因ID: 842
蛋白序列: P55211
细胞定位: nucleus,mitochondrion,cytosol,apoptosome,
研究背景: CASP9 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspase 9 can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. Caspase 9 is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.
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